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Medications: Medicines, including antidepressants like Selective Serotonin Reuptake Inhibitors (SSRIs), blood pressure pills, cholesterol-lowering medicines, pain relievers, and certain anti-seizure medicines, can lead to decreased sexual desire in males

CENTRAL EFFECTS MC4R Hypothalamic MC4R The MC4R receptor is expressed in the paraventricular (PVN) and arcuate nuclei of the hypothalamus, which are integrators of sexual motivation, feeding control, and autonomic regulation

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The GLP-1 and GIP activity is designed to offset glucagons potential to raise blood sugar, so glucose control is preserved in the trials conducted so far