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Betensky DJ et al

Acta Neuropsychiatr 34:318329 Altamimi TR, Thomas PD, Darwesh AM, Fillmore N, Mahmoud MU, Zhang L, Gupta A, Al Batran R, Seubert JM, Lopaschuk GD (2018) Cytosolic carnitine acetyltransferase as a source of cytosolic acetyl-COA: a possible mechanism for regulation of cardiac energy metabolism

Reconstitution and preparation Both compounds arrive as lyophilized (freeze-dried) powder that requires reconstitution with bacteriostatic water before injection

Direct head-to-head trials are not yet available, but comparing across studies suggests retatrutide produces approximately 6-10 percentage points more weight loss than tirzepatide at equivalent treatment durations