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Per prescribing information, if palpitations or significant heart rate increases emerge during dose escalation, temporarily maintaining the current dose or slowing the titration schedule may allow the body to adapt
Similar concerns have been seen with lipid outcomes with an increase in total cholesterol after cessation of semaglutide to near pretreatment levels and loss of around two-thirds of the benefit in triglycerides, while positive changes in LDL-C and HDL-C were more modest but appeared more durable (Table 2) [73]
10.2337/diabetes.50.3.609 191 WaughN.CumminsE.RoyleP.ClarC.MarienM.RichterB.et al (2010)
& Dadkhah, F
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