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Though the mechanisms through which this drug might influence alcohol craving and consumption are not known, in theory semaglutides inhibition of the appetitive centers in the brain could lead to reduced cravings and appetite for things other than food, like alcohol and other drugs

But hair follicles have insulin receptors and respond to insulin-like growth factor 1 (IGF-1)

Specifically in regard to nausea, it tended to be most pronounced in the first 4 weeks of therapy in all phase III LEAD trials, with symptoms generally dissipating over the remainder of the study period

It was characterized in the literature as the first selective growth hormone secretagogue