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Studies indicate improvements in inflammatory markers, though again, distinguishing direct anti-inflammatory effects from those secondary to metabolic improvement remains challenging
9 Similarly, in a combined analysis of the PARADIGM-HF (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) and PARAGON-HF (Prospective Comparison of ARNI with ARB Global Outcomes in HF with Preserved Ejection Fraction) trials suggested that patients with HFmrEF would most likely benefit from sacubitril/valsartan compared with renin-angiotensin system inhibitors, which was not the case in those with truly normal LVEF
Gene Expr Patterns
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