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As we mentioned above, rapid weight loss can lead to bone loss, too
Research from GLP-1 receptor agonist trials shows that semaglutide promotes proportionally greater fat loss than lean mass loss, but adequate protein intake remains important for muscle preservation
When calorie intake drops, the body pulls from both fat stores and muscle tissue
However, a 2024 study involving over 2,000 participants found that gradually tapering the dose , rather than stopping suddenly, helped many individuals maintain their weight loss
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