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Jennifer Ho, MD, associate professor of medicine at Harvard Medical School, Boston, Massachusetts, said, This really is a practice-changing trial and cements this type of therapy as one of the cornerstones of obesity and HFpEF treatment. Other experts cited a recently published pooled analysis of semaglutide trials looking specifically at patients with HFpEF and found lower rates of HF events with the GLP-1 agonist
In fact, the pharmacokinetics (how the drug is absorbed and processed) are designed for slow, steady release from a once-weekly injection
Factors Affecting Progress : Diet, exercise, other medications, and underlying health conditions can impact how well GLP-1 medications work
However, severe or persistent constipationespecially if accompanied by severe abdominal pain, bloating, vomiting, or inability to pass stool for more than a weekrequires immediate medical evaluation
