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The first line of defense against superoxide is the presence of a specific member of the family of metalloenzymes called superoxide dismutases (SODs), MnSOD or SOD2, specifically located in the mitochondrial matrix, which catalyzes the dismutation of superoxide anion into H 2 O 2 as shown in Figure 2
Expression of Ngn3 directs differentiating secretory progenitors toward endocrine fate, while expression of Neurod1 directs differentiating EEC progenitors toward EECs such as L-cells
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