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In the hypothalamus, liraglutide directly accessed the proopiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neurons expressing the GLP-1R, and appeared to be internalized, as expected when a GPCR ligand activates its receptor (117)
Additional research involving broader patient populations will be needed to determine whether semaglutide itself contributes to risk or whether other health conditions may explain the findings
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