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Theoretically, nanoparticles (NPs) encapsulating GLP-1RAs can significantly extend the drugs half-life and promote accumulation of the drug in the joint cartilage, thereby maintaining a high therapeutic concentration for an extended period and improving treatment efficacy
Weight loss : Mazdutide showed 20.1% at 60 weeks (Phase 3) versus survodutide's 18.7% at 46 weeks (Phase 2 on-treatment)
Wegovy slows gastric emptying as part of its mechanism to promote satiety, which can lead to constipation and changes in bowel habits
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