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Huang, C

Xenobiotics may be detoxified in conjugation reactions with glutathione catalyzed by glutathione S-transferase, which activity is constitutive

Beyond the observed increase in female lifespan, we show that pharmacologic blockade of IGF-1R signaling preserves, to various degrees, many aspects of healthspan, including neuromuscular function and endurance, and attenuates the age-related increase in diastolic dysfunction, systemic inflammation, and neoplasias in females

During the acquisition period, the mice were first placed in the light compartment, followed by opening of the guillotine door 10 s later, and measurement of their transition times to the dark compartment using a digital timer (Table 2)