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However, in-situ bioremediation is not without its challenges, especially when dealing with low-level pollution

Specifically, in hypoxic polymorphonuclear MDSCs, upregulation of the fatty acid transporter FATP2 promotes the uptake of peroxidation-sensitive arachidonic acid (AA), whereas in neutrophils with decreased expression of the lysophospholipid acyltransferase MBOAT1, the accumulation of PUFA-containing phosphatidylethanolamine causes this metabolic vulnerability

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Whether this increases melanoma risk in healthy individuals without pre-existing melanocytic pathology is uncertain, but the concern is biologically plausible and not merely theoretical