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The Cosmetic Ingredient Review Expert Panel reviewed it and concluded it's safe for use in cosmetics and recognized it as non-irritating, non-sensitizing, and non-comedogenic in skincare

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Our findings indicate that FOXO4-DRI promotes apoptosis in senescent cells by disrupting the FOXO4-P53 interaction, thereby releasing and phosphorylating P53, which then translocates to the cytoplasm