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For weight management, lack of at least 5% weight loss by 12 weeks at the maintenance dose warrants discussion about alternative strategies or dose optimization

The strategy is enhanced by coupling it with a fasting-mimicking diet, which upregulates the CMA machinery and the targeted receptor on tumor cells, creating a metabolically primed environment for efficient oncoprotein clearance and tumor suppression (Table 1) (Fig

However, if used in combination with other diabetes medications that can lower blood sugar (such as insulin or sulfonylureas), there can be an increased risk

Another common question involves duration