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For efficacy outcomes, in case trials reported results for different estimand analyses, we preferably extracted data for the efficacy estimand, which represents on-treatment efficacy without the influence of rescue therapy [14]

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Cell Death Differ 14:12111221 Dieck ST, Heuer H, Ehrchen J, Otto C, Bauer K (1999) The peptide transporter PepT2 is expressed in rat brain and mediates the accumulation of the fluorescent dipeptide derivative beta-Ala-Lys-Nepsilon-AMCA in astrocytes