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Downregulation of the skeletal muscle pyruvate dehydrogenase complex in the Otsuka Long-Evans Tokushima fatty rat both before and after the onset of diabetes mellitus

Stratified by GLP-1 related and non GLP-1 related treatments In the included RCTs, GLP-1 related drugs (including liraglutide, semaglutide, beinaglutide, exenatide, and AMG133) showed significant weight regain compared with control group (WMD = 1.78 kg, 95% CI 0.76 to 2.80, P = 0.006, I 2 = 85%)

Nasser, M., Javaheri, H., Fedorowicz, Z., and Noorani, Z

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