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The other recent, major arrival is orforglipron (Foundayo), a small-molecule oral GLP-1 from Eli Lilly that the FDA approved for chronic weight management in April 2026
Where semaglutide activates one receptor (GLP-1) and tirzepatide activates two (GLP-1 and GIP), retatrutide adds glucagon receptor agonism
Only a small number of GLP-1 medications are FDA-approved specifically for weight lossothers are typically used for type 2 diabetes management
Some newer medications such as Byetta for diabetes recommends using 30 or 31 gauge 1/3 inch needles which are ultra fine
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