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Multiple molecular mechanisms have been implicated in PD pathogenesis, including mitochondrial dysfunction, oxidative stress, impaired protein degradation pathways (ubiquitin-proteasome and autophagy-lysosomal systems), excitotoxicity, calcium dysregulation, neuroinflammation, and abnormal alpha-synuclein aggregation

Incubation with Universal LSA B2 KIT/HRP visualization reagent (K0675, Agilent, Santa Clara, CA, USA) was then performed for 20 min at room temperature

They carried the lowest weight

Vitamin B12 injections are a vital treatment for those with pernicious anaemia, a condition characterized by a lack of intrinsic factor a protein that binds and absorbs vitamin B12