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82 The promising mechanism of action of TLK286 and its positive preclinical data have sparked a series of clinical trials where the prodrugs have been applied alone or in combination with other standard chemotherapeutic agents
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The overall objective of this my research is to characterize the diversity and dietary regulation of cytochrome P450s, glutathione S-transferases, and multixenobiotic transporters in a generalist marine mollusc Cyphoma gibbosum that feeds on chemically defended prey, and to identify dietary natural products that act as substrates for these proteins
This review explores the multiple mechanisms through which metformin exerts its antitumor effects, focusing on signaling pathways such as AMPK/mTOR, ferroptosis, autophagy, apoptosis and chloride ion channels (CLIC1)
