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We have demonstrated the beneficial effect of G49, a dualAG, in resolving metabolic-dysfunction associated steatohepatitis (MASH) and improving liver regeneration under this pathological condition in C57BL/6J mice by targeting multiple homeostatic mechanisms including inflammation, oxidative/endoplasmic reticulum stress, mitochondrial dysfunction, and shifting glucose metabolism 13

Phase 2 trial - New England Journal of Medicine, 2023 Average drop in liver fat after 24 weeks in a smaller fatty-liver sub-study, measured against each person's starting level

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