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Most people with endogenous excess uric acid production appear to have a salvage pathway, and FA promotes uric acid synthesis through the purine salvage pathway by activating hypoxia-inducible factor-1 (HIF-1) to upregulate the expression of purine metabolism-related enzymes (100102)
Additionally, 3 of the 12 admitted patients were concomitantly taking insulin and 1 patient was on sulfonylurea therapy
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Kelly and Pearce, 2020
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