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The total RNA of the samples was extracted with Trizol reagent (Invitrogen, USA) according to the manufacturers instructions
case-by-case assessment) Severe uncontrolled depression, anxiety, or eating disorders (risk of worsening) Pregnancy or intent to become pregnant (GLP-1 safety in pregnancy not established
When stratified by administration route, the average percentage reductions were: Intramuscular (IM): 48.3% Sublingual: 30.7% Oral: 30.3% These results suggest that IM administration leads the most pronounced homocysteine reduction, however, sublingual and oral routes also demonstrate clinically relevant effects
Moon JH, Cho CH, Son GH, Geum D, Chung S, Kim H, et al
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