retatrutide overdose symptoms Since January 2026, there have been six cases of acute liver toxicity associated with unapproved peptide products labelled in Australia. These toxic effects may be linked to a contaminant in the Warning issued over counterfeit weight-loss

Furthermore, by addressing metabolic dysfunction in obese patients, whose prevalence is increasing in the IBD population (13), GLP-1 RAs could indirectly mitigate inflammation by decreasing the pro-inflammatory activity of adipose tissue, particularly visceral adipose one

Obese individuals seem to lose their ability to respond to satiety signals

Yet, in many countries the devices being used to deliver GLP-1s are the same for both the weight loss and T2D populations and, in many cases, were originally designed for delivering insulin, such as Novo Nordisks FlexTouch pen (Wegovy, semaglutide) or Eli Lillys KwikPen (Mounjaro, tirzepatide) outside the US

You can work with your provider to implement any lifestyle shifts and medication changes accordingly