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In this study, a number of SmTGR variants were produced to develop evidence for the role of specific active site residues and thus confirm the pathway of electron transmission, while also attempting to perturb and/or reveal other elements of the catalytic mechanism (Figure 2)

This could mean using baseline stool analyses to guide therapy selection for example, a PD patient lacking SCFA-producers might benefit most from a butyrate-producing probiotic, whereas one with high Enterobacteriaceae might need a targeted phage or antibiotic to reduce endotoxin load

3 Data Sources : A PubMed search was completed in Clinical Queries using the key terms vitamin B 12 , cobalamin, deficiency, and treatment

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