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It plays a role in gene expression and helps improve mitochondrial function

Document clinical contraindication to semaglutide: Persistent nausea or vomiting preventing dose escalation beyond initial doses, a documented thyroid concern (e.g., personal or family history of MEN 2 or medullary thyroid carcinoma), or another clinically documented intolerance can serve as the basis for the exception request

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For lifecycle management purposes, NCI exclusivity is the mechanism that gives commercial value to indication expansion programs