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GLP-1 agonists were originally approved by the U.S
Studies show that silymarin can be effective at doses of 200-600mg per day for most users.2 Silymarin is lipophilic and hydrophobic, meaning that it has an affinity for fats and is largely insoluble in water
GLP-1 receptor agonists e.g., semaglutide, liraglutide commonly cause gastrointestinal adverse effects such as nausea, vomiting, diarrhea, constipation, and abdominal discomfort, especially during dose escalation, less common risks include pancreatitis, gallbladder disease, and hypoglycemia mainly with insulin sulfonylureas
Litchfield DW
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