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Serious but Rare Side Effects Both medications carry warnings for more serious but uncommon side effects, occurring in less than 1-2% of patients: Pancreatitis (inflammation of the pancreas) Kidney problems Severe allergic reactions Thyroid tumors (seen in animal studies) Gastroparesis (delayed stomach emptying) Serious stomach issues Vision problems in some diabetics Retatrutides side effect profile appears similar to that of other incretin-based medications, though long-term safety data remains limited due to its investigational status
Therefore, the complementary mechanisms of action of an SGLT2 inhibitor and a GLP1-RA (through its efect to reduce appetite and possibly also its ability to slow gastric emptying) may provide an attractive approach for obesity treatment (Fig
5 #4 Avoid prolonged sun exposure Prolonged sunlight exposure can degrade glutathione levels in the skin, reducing its effectiveness as an antioxidant and diminishing its skin health benefits
Brand-name medications Mounjaro and Zepbound are approved by the FDA for different indications
