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Sucher NJ, Lipton SA (1991)
Recent findings suggest that many of the memory enhancing effects originally attributed to AngII acting at the AT1 receptor subtype were due to the conversion of AngII to angiotensin III (AngIII) and then to the hexapeptide angiotensin IV (Ang IV) and it were AngIV activation of the AT4 receptor subtype that facilitated memory consolidation and retrieval [62-64]
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Aware of this work, Charles Janeway and Ruslan Medzhitov overexpressed a modified version of human TLR4 (which they called 'h-Toll') and found it capable of activating the transcription factor NF-B in mammalian cells
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