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The BMJ

Introduction Glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT-2) inhibitors are second to third line antihyperglycaemic drugs commonly prescribed for the treatment of type 2 diabetes.12 Individually, these drugs have been shown to reduce the risk of cardiorenal events and mortality in large cardiovascular outcome trials.3456789 However, the combined effect of these drug classes on these outcomes has not been extensively studied

December 22, 2025

Previous GLP-1 medication use If you are switching from tirzepatide to retatrutide or from semaglutide, your body has already adapted to GLP-1 receptor activation