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Liraglutide depolarizes membrane potential and increases the spontaneous action potentials directly through postsynaptic GLP-1R in the ARC neurons expressing POMC (Secher et al., 2014
It functions as a dual GLP-1/GIP receptor agonist, meaning it imitates the hormones GLP-1 and GIP, which naturally manage appetite and blood sugar
While the long-term effects are not known, people have reported 111 potential side-effects to the Medicines and Healthcare products Regulatory Agency (MHRA) in the last 10 years
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