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The final covariate models for subject ( i ) and dosing occasion ( j ) were parameterised as follows: where In the above equations, is the estimated (or fixed) value for each covariate, ka.long.fast is the absorption rate constant for fasting times of 120 min or longer, i is the subject-level random effects, j is the occasion-level random effects
Further exclusion criteria encompassed patients with pre-existing chronic liver conditions or type 1 diabetes mellitus to minimize confounding effects
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The SUSTAIN studies confirmed that, in addition to their effect on glycemic and weight control in patients with type 2 diabetes, GLP1RAs have the potential to reduce the incidence of major adverse cardiovascular outcomes in high-risk populations
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