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DPP-4 rapidly degrades both GLP-1 and GIP (T1/2~4-5 minutes
No specific DSIP receptor has ever been identified, the original sleep-induction findings have proved difficult to replicate consistently, and its status as a genuine endogenous sleep factor remains contested nearly fifty years after its description
Novo Nordisk also spent several years trying to develop an oral formulation of insulin that could replace injections, but abandoned the project in 2022
Should we withhold potentially beneficial treatment while we wait
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