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J Neurosci 27:77777785 Schmidlin CJ, Dodson MB, Madhavan L, Zhang DD (2019) Redox regulation by NRF2 in aging and disease

The following occurred in the respective cases: sodium and chloride depletion fluid overload septicemia, or blood poisoning, in an individual with existing compromised liver function and portal hypertension While underlying conditions may have increased the risk of severe side effects or death in some cases, these findings suggest that coffee enemas are generally not safe