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Long-Term Management of B12 Deficiency Managing vitamin B12 deficiency in the long-term typically involves: Regular B12 supplementation, either through injections or oral therapy Dosage can vary from 1 to 5 mg daily Administered over a period of one to four months or until laboratory results indicate improvement in hematologic and/or neurologic functions Consult with a healthcare professional for personalized advice on managing vitamin B12 deficiency in the long-term and determining the most appropriate supplementation method for you