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The REDEFINE 4 trial: the definitive showdown Everything discussed above relies on cross-trial comparisons, which carry inherent limitations

Key takeaways Contrave (naltrexone/bupropion) is a twice-daily oral tablet, while Wegovy (semaglutide) is either a weekly injection or a daily oral tablet

Most participants approach weight loss plateau around weeks 40-48, though clinical trial data showed participants were still losing weight at study conclusion, suggesting even longer treatment courses might yield additional benefits

However, Wegovy's standardized formulation offers consistent results and has undergone rigorous testing for safety and efficacy