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PMID: 11325542

Favale, G., et al

To help manage GLP-1 medication side effects, doctors usually start with a low dose and slowly increase the dose month-by-month, she says

It works by binding to the ghrelin receptor (GHS-R1a) in the hypothalamus and pituitary, triggering a calcium/PKC signaling cascade that releases stored growth hormone, while separately blunting somatostatin's inhibitory signal