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J Headache Pain 19(1):55 Wang W, Zhang X, Bai X et al (2023) Changes in gamma-aminobutyric acid and glutamate/glutamine levels in the right thalamus of patients with episodic and chronic migraine: A proton magnetic resonance spectroscopy study

Can people use hot baths, with the appropriate warning, of course, that, without getting into description of the mechanics and the underlying biology, it's pretty obvious that the testes, if they get too warm, you'll kill a sperm

While acute cortisol increases may be tolerable, protocols involving frequent or long-term administration would ideally avoid this confound