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Digestion 56:493501 Lee A, Patrick P, Wishart J, Horowitz M, Morley JE (2002) The effects of miglitol on glucagon-like peptide-1 secretion and appetite sensations in obese type 2 diabetics

The first GLP-1s secured approval as diabetes therapies in 2014, but uptake was slow given that they required daily injections and weight loss was limited

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13,7 % Poblacin Comparacin directa en obesidad Pptido Retatrutida Dosis 12 mg/semana Duracin 48 semanas Reduccin de peso ~24,2 % Poblacin Obesidad, sin diabetes Pptido Retatrutida Dosis Dosis mximas Duracin Fase 3 Reduccin de peso ~28,7 % Poblacin Obesidad + osteoartritis Nota importante: Los valores no son directamente comparables porque las poblaciones y los diseos de los estudios difieren