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Sermorelins pituitary-signaling behavior is discussed in more detail in our reference on how sermorelin affects pituitary signaling in endocrine research
2.5 Model Predictions Because of substantial log-normal within-individual variability, standard computation of reference subject simulations, as well as population predictions and weighted residuals reported by the nonlinear mixed-effects modelling software (NONMEM) are poor measures to reflect data
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