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Extended Half-Life Technology The LR3 modification involves 13 amino acid substitutions that reduce binding to IGF-binding proteins, allowing the peptide to remain active in the bloodstream for significantly longer periodstypically 20-30 hours compared to natural IGF-1s few hours

The highest dose of Eli Lillys once-daily treatment helped patients lose about 12.4% of their body weight in a late-stage trial, well below analyst expectations of 15%, according to FactSet

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Doctors have described them as game changers in obesity treatment, and some people using the drugs who've struggled with obesity have said they've never felt better