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Ipamorelin is a selective pentapeptide agonist of the growth-hormone secretagogue receptor (GHSR-1a), documented in published research for GH release without measurable prolactin or cortisol elevation

They also alter renal natriuresis and diuresis via effects on proximal tubule cells, providing a postulated mechanism for the emerging evidence of renoprotection with this class of drugs (51) (Figure 4)

In light of this evidence, it is likely that future guidelines will incorporate these therapies into the standard of care for MASLD, alongside resmetirom

Muscle matters: the effects of medically induced weight loss on skeletal muscle