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Microglial cells act as a first defence line for CNS microenvironment, which is activated minutes to a few hours following ischemia
Annu Rev Pharmacol Toxicol , 45:5188
doi: 10.1007/s00125-018-4776-y 68
Factors that contribute to its development include: Hormonal fluctuations (pregnancy, birth control pills, hormone therapy) Genetic predisposition UV exposure and photoaging Emotional stress Sleep disturbances Photosensitizing medications Chronic inflammation What makes melasma particularly frustrating is its multifaceted nature
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