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In summary, GSHee and L-CYSee 21 may represent the first examples of a novel class of thiolester compounds that are able to effectively prevent the ventilatory depressant effects of powerful opioids such as fentanyl (and perhaps other high potency opioids such as sufentanil and alfentanil) and their deleterious effects on breathing stability and gas-exchange within the lungs without compromising the analgesic actions of the opioids

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In the United States, the Food and Drug Administration (FDA) does not regulate dietary supplements the way it regulates prescription medications