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Energy and focus support: Caloric restriction can impair energy and cognitive function

Hair loss concerns have also emerged in community discussions, though clinical trial data on this specific side effect is limited

Weight loss typically becomes noticeable within the first month and continues progressively

The SUSTAIN clinical trial programme has documented Semaglutides superior glycaemic and weight-reducing efficacy relative to placebo, sitagliptin, exenatide extended-release, insulin glargine, and dulaglutide establishing Semaglutide as the highest-efficacy selective GLP-1R agonist in comparative clinical pharmacology and providing the translational reference dataset for pre-clinical mechanistic research into the molecular basis of its superior outcomes