Estudio de ajuste flexible de la dosis: En un estudio de 52 semanas, abierto, 504 pacientes con diabetes tipo 2 fueron asignados al azar a Rybelsus (ajuste flexible de la dosis de 3 mg, 7 mg y 14 mg, 1 vez al da) o sitagliptina de 100 mg, 1 vez al da, todos en combinacin con 1-2 medicamentos orales para reducir la glucosa (metmorfina, inhibidores del SGLT2, sulfonilurea o tiazolidinedionas)
A., Malloy, V., Krajcik, R
GLP-1 receptors are expressed in multiple brain areas in rodents, primates, and humans and they are involved in learning, neuroprotection and regulation of appetite and satiety ( Previous study has shown that vagal afferent neuron GLP-1 receptors play a crucial role in mediating the effects of GLP-1 on food intake and glycemia (Supplementary Figure 2)
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