It acts as a growth hormone (GH) secretagogue stimulating levels of GH and insulin-like growth factor 1 (IGF-1), while preserving GH pulsatility
has received grant funding (past and present) from: NIMH (USA), CIHR (Canada), NARSAD (USA), Stanley Medical Research Institute (USA), MRC (UK), Wellcome Trust (UK), Royal College of Physicians (Edinburgh, UK), BMA (UK), UBC-VGH Foundation (Canada), WEDC (Canada), CCS Depression Research Fund (Canada), MSFHR (Canada), NIHR (UK) and Janssen (UK) EU Horizon 2020
Regular kidney function monitoring is essential for metformin safety
Downregulation of senescence-associated secretory phenotype by knockdown of secreted frizzled-related protein 4 contributes to the prevention of skin aging