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Tein I, Xie ZW: Reversal of valproic acid-associated impairment of carnitine uptake in cultured human skin fibroblasts

Subsequently, this effect is reversed by the decreasing Nrf2 levels in the nucleus (nNrf2), leading to a decreased Keap1 level that is accompanied by a recovery of unbound Nrf2 because of a decreased sequestration in complexes with Keap1 (Fig 3C

While there is not much doubt that traumatic disc herniation can occur in a degenerated segment, 5 and, although documented in biomechanical in-vitro studies, 39 the existence of an isolated annulus fiber rupture with NP herniation caused by a single traumatic event without (proven) pre-existing DD is still debated in the clinical literature

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