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A patient on maximum-dose semaglutide (2.4 mg weekly) does not typically start tirzepatide at 15 mg
The tradeoff is significant: trial participation involves randomization (you may receive a placebo), strict eligibility criteria, and frequent clinic visits
All participants were on metformin at the maximum tolerated dose according to clinical and laboratory parameters (mean dose = 1500 mg), and none were taking other antihyperglycemic drugs including insulin analogues
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