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Furthermore, the requirement for patients to have an available weight measurement on the index date and after 1 year of follow-up and to be persistent on therapy for 1 year may have introduced potential selection bias in favor of patients who are more actively managed and/or for whom treatment is effective

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Clinical research demonstrates reductions in adipocyte size of 30-40%, with preferential targeting of visceral adipose tissue

These agents help the liver break down and transport fat , prevent fat accumulation , and support methylation , a key biochemical pathway for detoxification, mood balance, and DNA repair