Binding of mTORC1 requires the RagA/B.GTP and RagC/D.GDP conformation, being determined by lysosomal Ragulator, acting as specific GTP exchange factor (GEF) of Rags, and by lysosomal Gator1 and Folliculin-FNIP2 which function as GTPase activation proteins (GAP) for RagA/B and RagC/D, respectively
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Finally, many studies have interrogated the role of requisite amino acids (i.e., cysteine, glutamate, and glycine) or metabolic cofactors that regenerate GSH (i.e., NADPH) 20,21,22,23,24,25 in GSH synthesis
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